Wednesday, November 20, 2024
| Registration and welcome |
| 12.30 pm-1.00 pm
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| Welcome address |
| 1.00 pm-1.15 pm
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1.00 pm |
Sylvain Brisse, Conference Chair
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1.10 pm |
Member of IP management board, tbc
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| Opening session |
| 1.15 pm-3.00 pm
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| Chairs: Sylvain Brisse, Institut Pasteur, France - Chiara Crestani, Institut Pasteur, France |
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1
1.15 pm |
Keynote
Genomic insights into Kpn biology and epidemiology
Kat Holt
London School of Hygiene & Tropical Medicine, London, United Kingdom
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2
2.00 pm |
Clinical and molecular epidemiology of invasive Klebsiella pneumoniae: An African experience
Shabir Madhi
Vaccines and Infectious Diseases Analytics Research Unit, University Of The Witwatersrand, Johannesburg, South Africa
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3
2.30 pm |
Burden and management of Kpn infection: an American/European perspective
Christian Giske
Karolinska Institute, Stockholm, Sweden
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| Coffee break |
| 3.00 pm-3.30 pm
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| Session 1: Epidemiology in humans |
| 3.30 pm-5.30 pm
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| Chairs: Kat Holt, London School of Hygiene & Tropical Medicine, United Kingdom - Arnfinn Sundsfjord, The Arctic University of Norway, Norway |
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4
3.30 pm |
Genomic insights unveil the plasmid transfer mechanism and epidemiology of hypervirulent Klebsiella pneumoniae in Vietnam
Quynh Nguyen
Oxford University Clinical Research Unit, HCMC, Vietnam, Ho chi Minh, Vietnam
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5
3.45 pm |
Different transmission patterns between 3GC- and carbapenem-resistant Klebsiella pneumoniae
Fernando Gonzalez-Candelas
Joint Research Unit Infection and Public Health, University of Valencia - FISABIO, Valencia, Spain
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6
4.00 pm |
Escalating Burden and Mortality of Klebsiella Infections in Young Infants in Bangladesh: A Prospective Genomic Epidemiology Study Over 18 Years
Yogesh Hooda
Child Health Research Foundation, Dhaka, Bangladesh
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7
4.15 pm |
Whole-Genome Sequencing reveals potential Klebsiella pneumoniae ST14 outbreaks in Kiambu County and Mbagathi Subcounty Hospitals of Kenya in 2021 and 2022 respectively
Wilson Gumbi
Bioscience Department, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
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8
4.30 pm |
Trends of Clonal Lineage Evolution and Emergence Among Carbapenem-Resistant K. pneumoniae in Indian Hospital Environments
Geetha Nagaraj
CRL, KIMS, Bangalore, India
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9
4.45 pm |
High-risk K. pneumoniae clones and mobile elements in Chile and South America: empowering the National AMR Surveillance with genomics
Andres Marcoleta
Grupo de Microbiologia Integrativa, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
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| Poster pitches 1 (15 posters x 1 minute) |
| 5.30 pm-5.50 pm
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| Session 2 BMGF: Klebsiella pneumoniae in LMICs: the path toward a maternal vaccine |
| 5.50 pm-6.50 pm
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| Chairs: Usman Nakakana, Bill & Melinda Gates Foundation, United States - Nicole Benson, Bill & Melinda Gates Foundation, United States |
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10
5.50 pm |
Klebsiella pneumoniae as an important infectious cause of death in infants in LMIC settings and the potential value of a maternal vaccine
Ziyaad Dangor
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11
6.10 pm |
Current insights on the development of a Klebsiella pneumoniae vaccine
Francesca Micoli
Gvgh, Siena, Italy
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12
6.25 pm |
Current progress of Inventprise’s glycoconjugate vaccine development against Klebsiella pneumoniae for prevention of neonatal sepsis
Heather Fox
Inventprise, Inc, Redmond, United States
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0
6.35 pm |
Questions & Answers
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| Poster pitches 2 (15 posters x 1 minute) |
| 6.50 pm-7.10 pm
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| Welcome reception & Poster session 1 |
| 7.10 pm-9.30 pm
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Thursday, November 21, 2024
| Morning coffee |
| 08.30 am-09.00 am
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| Session 3: Ecology and One Health |
| 09.00 am-10.30 am
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| Chairs: Edward Feil, University of Bath, United Kingdom - Iren Høyland Löhr, Stavanger University Hospital, Norway |
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13
09.00 am |
Klebsiella pneumoniae epidemiology through a One Health lens: Genomic insights into population dynamics across human, animal, and marine sources in Norway
Marit Hetland
Stavanger University Hospital, Stavanger, Norway
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14
09.30 am |
Genomic Diversity, Virulence, and Antimicrobial Resistance Profiles of Klebsiella pneumoniae in Madagascar: A One Health Approach
Lala Rafetrarivony
Experimental Bacteriology, Pasteur Institute of Madagascar, Antananarivo, Madagascar
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15
09.45 am |
Emergence of carbapenem-resistant Klebsiella pneumoniae isolates in French companion animals
Marisa Haenni
Unité Antibiorésistance et Virulence Bactériennes, Université de Lyon - Anses, Lyon, France
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16
10.00 am |
Class A beta-lactamases are core genes of the Klebsiella planticola and Klebsiella terrigena species complexes
Lesley Hoyles
Biosciences, Nottingham Trent University, Nottingham, United Kingdom
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17
10.15 am |
Deciphering phylogenetic and acquired drivers of ecological adaptation in the Klebsiella pneumoniae species complex
Jose F Delgado-Blas
Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Université de Paris, Paris, France
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| Coffee break |
| 10.30 am-11.00 am
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| Session 4: Klebsiella molecular biology |
| 11.00 am-12.30 pm
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| Chairs: Guido Werner, Robert Koch Institute, Germany - Olaya Rendueles, CNRS, France |
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18
11.00 am |
Single amino acid polymorphism dictates the offensive versus defensive type VI secretion system behaviour affecting horizontal gene transfer in Klebsiella pneumoniae.
Alix Lee
Queen's University Belfast, Belfast, United Kingdom
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19
11.15 am |
RNA-RNA interactome of hypervirulent K. pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and pathogenesis in mice
Yanjie Chao
Shanghai Insititute of Immunity and Infection (Former Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai, China
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20
11.30 am |
Dynamics of Klebsiella pneumoniae bacteremia
Michael Bachman
Michigan University, Ann Arbor, United States
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21
12.00 pm |
K. pneumoniae K64 capsule serotype: a facilitator of hypervirulence and multidrug resistance convergence?
Julie Le Bris
Microbial Evolutionary Genomics Unit (CNRS UMR3525), Department of Genomes & Genetics, Institut Pasteur, Paris, France Collège Doctoral, Ecole Doctorale Complexité du Vivant, Sorbonne Université, Paris, France
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22
12.15 pm |
Discrete environmental cues regulating Klebsiella pneumoniae mucoidy
Laura Mike
Dept of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, United States University of Toledo, Toledo, United States
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| Lunch (buffet) |
| 12.30 pm-2.00 pm
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| Session 5: Host-pathogen interactions |
| 2.00 pm-3.30 pm
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| Chairs: Christiane Forestier, Université Clermont Auvergne, France - Margaret Lam, Monash University, Australia |
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23
2.00 pm |
Klebsiella goes on the offensive: T6SS-dependent manipulation of vascular physiology
José Bengoechea
Queen’s University Belfast, Belfast, United Kingdom
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24
2.30 pm |
Klebsiella pneumoniae SEFIR domain encoded effector - a new immune evasin
Joana Sa Pessoa
Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom
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25
2.45 pm |
Bolstering the immune system for improved defense against Klebsiella pneumoniae
Shekina Gonzalez-Ferrer
University of Pittsburgh, Pittsburgh, United States University of California, Los Angeles, United States
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26
3.00 pm |
Phase variation of mucoid capsule in hypervirulent Klebsiella pneumoniae
Joseph Wanford
King's College London, London, United Kingdom
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27
3.15 pm |
Seeing what sticks: how hypermucoviscosity-associated rmp genes impact classical Klebsiella pneumoniae virulence
Stephen Salisbury
Micro & Immuno, Virginia Miller lab, University of North Carolina - Chapel Hill, Chapel Hill, United States
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| Coffee break |
| 3.30 pm-4.00 pm
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| Session 6: Infection models |
| 4.00 pm-5.30 pm
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| Chairs: José Bengoechea, Queen’s University Belfast, United Kingdom - Yunn-Hwen Gan, National University of Singapore, |
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28
4.00 pm |
Klebsiella pneumoniae: silent colonizer to rowdy invader
Ammar Zafar
Wake Forest University School of Medicine, Winston-Salem, United States
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29
4.30 pm |
Application of Various Murine Models to Probe Klebsiella pneumoniae Pathogenesis, Host Immunity, and Therapeutic Efficacy
David Rosen
Dept. of Pediatrics, Washington University, St. Louis, United States
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30
5.00 pm |
Antibiotic treatment failure of liver abscesses caused by hypervirulent Klebsiella pneumoniae
Sarah Rowe-Conlon
Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, United States
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31
5.15 pm |
In vivo single-cell high-dimensional mass cytometry analysis to track the interactions between Klebsiella pneumoniae and myeloid cells
Ricardo Calderón González
Wellcome-Wolfson Institute For Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom
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| Poster session 2 |
| 5.30 pm-6.30 pm
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| Conference dinner |
| 7.30 pm-10.00 pm
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Friday, November 22, 2024
| Session 7: Genomics and evolution |
| 09.00 am-11.00 am
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| Chairs: Kelly Wyres, Monash University, Australia - Sylvain Brisse, Institut Pasteur, France |
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32
09.00 am |
Delivering genomic interpretation for local value, and towards national and international policy
David Aanensen
Oxford University, Oxford, United Kingdom
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33
09.30 am |
Title to be confirmed
Olaya Rendueles
CNRS, Toulouse, France
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34
10.00 am |
A metabolic atlas of the Klebsiella pneumoniae Species Complex
Ben Vezina
Department of Infectious Diseases, Monash University, Melbourne, Australia Centre to Impact AMR, Monash University, Clayton, Australia
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35
10.15 am |
Plasmidomics of a global collection of Klebsiella pneumoniae reveals diverse routes for the convergence of resistance and virulence genes
Melissa Martin
Multidrug Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, United States
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36
10.30 am |
Deciphering transmission patterns of NDM-1 producing Klebsiella pneumoniae: Spread of different NDM-1 carrying plasmids across four different hospital sites in Berlin, Germany
Anna Weber
Institute of Hygiene and Environmental Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany
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37
10.45 am |
The role of genetic background on the emergence and spread of antibiotic resistance in Klebsiella pneumoniae
Evan Snitkin
Microbiology and Immunology, University of Michigan, Ann Arbor, United States
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| Coffee Break |
| 11.00 am-11.30 am
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| Session 8: Vaccines and Novel therapeutic approaches |
| 11.30 am-1.00 pm
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| Chairs: Michael Bachman, Michigan University, United States - Kat Holt, London School of Hygiene & Tropical Medicine, United Kingdom |
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38
11.30 am |
Phage therapy targets IBD-driving K. pneumoniae in the gut
Sara Federici
Weizmann Institute of Science, Rehovot, Israel
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39
12.00 pm |
A multi-valent Klebsiella pneumoniae capsule vaccine
Paeton Wantuch
Pediatric Infectious Disease, Washington University School of Medicine, Saint Louis, Mo, United States
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40
12.15 pm |
K-Vax, a new vaccine for prevention of disease by Klebsiella pneumoniae with potential for global strain coverage
Juan Jose Infante
VAXDYN, Dos Hermanas, Spain
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41
12.30 pm |
Anti-capsule human monoclonal antibodies protect against hypervirulent and pandrug-resistant Klebsiella pneumoniae
Anna Kabanova
Fondazione Toscana Life Sciences, Siena, Italy
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42
12.45 pm |
A community-driven resource for Klebsiella research identified a novel gut phage signature associated with chronic disease
Daniela Rothschild Rodriguez
University of Southampton, Southampton, United Kingdom
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| Panel discussion |
| 1.00 pm-2.00 pm
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| Moderator: Padmini Srikantiah, Bill & Melinda Gates Foundation, United States |
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0
1.00 pm |
How do you solve a problem like Klebsiella?
Focus on surveillance and infection control
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0
1.00 pm |
Michael Bachman
Michigan University, Ann Arbor, United States
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1.00 pm |
Amy Mathers
University of Virginia School of Medicine, Charlottesville, United States
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0
1.00 pm |
Kat Holt
London School of Hygiene & Tropical Medicine, London, United Kingdom
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0
1.00 pm |
Keith Klugman
Bill & Melinda Gates Foundation, Bonita Springs, United States
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0
1.00 pm |
Shabir Madhi
Vaccines and Infectious Diseases Analytics Research Unit, University Of The Witwatersrand, Johannesburg, South Africa
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| Closing session |
| 2.00 pm-2.10 pm
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